Tanaka N, Chakravarty AK, Maughan B, Shuman S. Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions. J Biol Chem. 2011 Dec 16;286(50):43134-43. doi: 10.1074/jbc.M111.302133. Epub 2011 Oct 31. PMID: 22045815; PMCID: PMC3234866.
RTCB同时含有CPDase活性和3'-P ligase活性，意味着RTCB的底物不只是2',3'-cyclic phosphate，还包括3'-phosphate。
后面一篇Science又证实了human RtcB可以连接3'P和5'-OH.
Comments
评论暂时关闭
当前不公开历史评论正文；仅保留隐私安全统计和本地审核材料。新评论入口暂时关闭，避免在审核、反垃圾和通知邮件策略未确定前接收公开提交。